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Placental blood and tissue are significant sources of stem cells that are more versatile than those found in cord blood. Placental stem cells can increase the chances of transplant success today and possibly emerge as treatments for other diseases in the future.

Bank the Placenta For More Life-Saving Stem Cells

Maximize the Number of Stem Cells Collected

When banking cord blood alone, a typical collection will yield 1.8 million CD34+ stem cells.1 Having a high number of CD34+ stem cells in your collection can improve the likelihood of a successful transplant.2 Placental blood also contain CD34+ hematopoietic stem cells, so adding stem cells from the placental blood to your cord blood collection can increase the number of CD34+ stem cells in your banked collection.3

More Cells Can Lead to Better Transplant Outcomes

If you need to use your collection for a transplant, numerous studies have shown that using more stem cells may improve survival in transplant patients.4,5

Lifebank By CelularityTM has pioneered placental stem cell banking to maximize the potential of your collection. In February 2023, Celularity’s proprietary research shows an average increase of 68% in CD34+ cells and 17% in TNC (Total Nucleated Cell count) when banking human placental-derived stem cells (HPDSC) in addition to human umbilical cord blood (HUCB).6 You can also watch Quentin’s story. He is the recipient of the world’s first cord and placental stem cell transplant, which was made possible by Lifebank.

Be Prepared for the Future of Regenerative Medicine

The Power to Divide into Specialized Cells

Placental tissue and cord tissue are rich in mesenchymal stem cells (MSCs) and mesenchymal-like stem cells, which are different from hematopoietic CD34+ stem cells found in cord blood. MSCs have demonstrated unique regenerative capabilities because they secrete exosomes that contain many growth factors and other messages to transform into a wide variety of cells and tissues.7,8,9 Current research shows that MSCs may someday play a role in healing tissues damaged by disease.8 Banking placental tissue and cord tissue permits greater capture of these powerful MSCs that may revolutionize regenerative medicine.10

Placental Blood and Tissue Stem Cells Are Packed with Potential

As of February 2023, 901 registered clinical trials in the United States have explored or are actively studying the possible applications of MSCs.11,12 They include applications ranging from neurodegenerative and cardiac disorders to COVID-19 and cancers.11 By deciding to bank placental blood and tissue in addition to cord blood, numerous possibilities of future applications for your stem cell collection emerge.

We hope this information helps you understand the value of placental banking as a complement to cord blood banking! Please review our Pricing & Packages and call us at 877-543-3226 when you are ready to enroll as a private client.

REFERENCES

  1. Parent’s Guide to Cord Blood Foundation. How much blood and stem cells does a typical umbilical cord hold? Available at: https://parentsguidecordblood.org/en/faqs/how-much-blood-and-stem-cells-does-a-typical-umbilical-cord-hold. Accessed February 26, 2023.
  2. Serikov V, Hounshell C, Larkin S, Green W, Ikeda H, Walter M, and Kuypers F. Human Term Placenta as a Source of Hematopoietic Cells. NCBI. 2009; 234(7):813-823. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389511/#:~:text=The%20placenta%20averaged%20a%20total,cord%20blood%20collection%20(10). Accessed February 26, 2023.
  3. Fajardo-Orduna G, Mayani H, et al. Human Mesenchymal Stem/Stromal Cells from Umbilical Cord Blood and Placenta Exhibit Similar Capacities to Promote Expansion of Hematopoietic Progenitor Cells in Vitro. Stem Cells International. November 9, 2017. Available at: https://www.hindawi.com/journals/sci/2017/6061729/. Accessed February 26, 2023.
  4. Dehn J, Spellman S, et al. Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR. Blood. 2019;134(12):924-934. Available at: https://ashpublications.org/blood/article/134/12/924/374909/Selection-of-unrelated-donors-and-cord-blood-units. Accessed February 26, 2023.
  5. Torlen J, Ringden O, et al. Low CD34 Dose is Associated with Poor Survival after Reduced-Intensity Conditioning Allogenic Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome. Biology of Blood and Marrow Transplantation. 2014;20(9):1418-1425. Available at: https://www.sciencedirect.com/science/article/pii/S108387911400319X. Accessed February 26, 2023.
  6. Celularity research data (updated February 2023), as reported by Sharonjeet Kalsi, Technical Operations.
  7. Nature Research. Mesenchymal stem cells. Available at: https://www.nature.com/subjects/mesenchymal-stem-cells. Accessed February 26, 2023.
  8. Ullah I, Subbarao R, Rho G. Human mesenchymal stem cells – current trends and future prospective. Bioscience Reports. 2015; 35(2). Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413017/. Accessed February 26, 2023.
  9. Iaquinta M, Mazzoni E, et al. Adult Stem Cells for Bone Regeneration and Repair. Frontiers in Cell and Developmental Biology. November 12, 2019. Available at: https://www.frontiersin.org/articles/10.3389/fcell.2019.00268/full. Accessed February 26, 2023.
  10. Zhao T, Feng S, et al. Emerging Role of Mesenchymal Stem Cell-derived Exosomes in Regenerative Medicine. Current Stem Cell Research & Therapy. 2019;14(6):482-494. Available at: https://www.ingentaconnect.com/content/ben/cscr/2019/00000014/00000006/art00006. Accessed February 26, 2023.
  11. Levy O, Kuai R, et al. Shattering barriers toward clinically meaningful MSC therapies. Science Advances. 2020;6(30). Available at: https://www.science.org/doi/10.1126/sciadv.aba6884. Accessed February 26, 2023.
  12. U.S. National Library of Medicine. Active Mesenchymal Stem Cell Clinical Trials. Available at: https://clinicaltrials.gov/ct2/results?term=mesenchymal+stem+cells&Search=Apply&recrs=b&recrs=a&recrs=f&recrs=d&recrs=e&age_v=&gndr=&type=&rslt=. Accessed February 26, 2023.
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